منابع مشابه
Thrombosis and Drug-Eluting Stents
Stent thrombosis (ST) after percutaneous coronary intervention has been the focus of intense interest because of its attendant morbidity and mortality. There is controversy about several facets of the problem. These include the frequency of ST with drug-eluting stents (DES) versus bare-metal stents (BMS), the timing of the event, clinical consequences, risk factors, adjunctive therapy, and new ...
متن کاملThrombosis after implantation of drug-eluting stents.
S tent thrombosis is the sudden occlusion of a stented coronary artery due to thrombus formation. Despite major improvements in antiplatelet therapy, thrombotic events remain the primary cause of death after percutaneous coronary interventions. The clinical consequences of stent thrombosis are frequently catastrophic and include death in 20% to 48% of cases or major myocardial infarction in 60%...
متن کاملThrombosis in Coronary Drug-Eluting Stents
Coronary drug-eluting stents (DES) were first approved for use in the United States in 2003 (Cypher Coronary Sirolimus-Eluting Stent [SES], Cordis Corporation, Miami Lakes, Fla) and 2004 (Taxus Express Paclitaxel-Eluting Stent [PES], Boston Scientific Corporation, Natick, Mass) on the basis of randomized, blinded, controlled studies that demonstrated reduced target vessel failure (Cypher) and t...
متن کاملThrombosis modulates arterial drug distribution for drug-eluting stents.
BACKGROUND Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as to whether thrombi affect drug elution and arterial uptake. METHODS AND RESULTS Paclitaxel transport and retention were assessed in clots of different blood components. Diffusivity, affected by clot organization, is fastest in fibrin (approximat...
متن کاملLate angiographic stent thrombosis (LAST) events with drug-eluting stents.
OBJECTIVES We sought to describe the incidence of late angiographic stent thrombosis (LAST) events in an unselected drug-eluting stent (DES) population. BACKGROUND Concerns have been raised that LAST may be a potential limitation of DES. METHODS We have previously reported the angiographic incidence of early stent thrombosis (1.0%) in this prospective cohort of 2,006 patients treated with e...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2007
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2007.04.032